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A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome
journal contribution
posted on 2023-05-25, 21:40 authored by Lean, SY, Adams, MJThe antiphospholipid syndrome (aPS) is a systemic autoimmune disorder that is characterised by laboratory markers of antiphospholipid antibodies (aPL) as well as clinical manifestations such as arterial and venous thrombosis, recurrent pregnancy loss and thrombocytopaenia. Although it is unclear precisely what mechanism(s) lead to thrombosis in aPS, it is probable that the contribution of aPL such as anti-˜í‚â§-2- glycoprotein-1 (anti-˜í‚â§2GP1) is signifi cant. Indeed, there is increasing evidence that aPL may interfere with the tissue factor (TF) pathway of blood coagulation and its natural regulator tissue factor pathway inhibitor (TFPI), thus contributing toward the development of thrombosis in aPS. This paper will therefore review 1) the TF pathway of blood coagulation and TFPI, 2) clinical and laboratory aspects of aPL and aPS, and 3) interactions of aPL with the TF pathway, to highlight the potential signifi cance of these in the pathogenesis of aPS.
History
Publication title
Australian Journal of Medical ScienceVolume
28Article number
3Number
3Pagination
99-107ISSN
1038-1643Publication status
- Published
Repository Status
- Restricted
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