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Genetic association between GHSR1a 5′UTR-microsatellite and nt-7(C>A) loci and growth and carcass traits in Japanese Black cattle

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Komatsu, M and Itoh, T and Fujimori, Y and Satoh, M and Miyazaki, Y and Takahashi, H and Shimizu, K and Malau-Aduli, AEO and Morita, M (2011) Genetic association between GHSR1a 5′UTR-microsatellite and nt-7(C>A) loci and growth and carcass traits in Japanese Black cattle. Animal Science Journal, 82 (3). pp. 396-405. ISSN 1740-0929

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Abstract

We carried out a genetic association study between five nucleotide polymorphisms (5′UTR microsatellite ((TG)n), nt-7(C>A), L24V, DelR242 and Intron 1 microsatellite) of the GHSR1a gene and growth and carcass traits in 1285 steers sired by 117 Japanese Black bulls in a progeny testing program. We report herein, a significant association between the 5′UTR microsatellite and nt-7(C>A) loci and growth and carcass traits. We also propose a translational hypothesis that the association is due to differences in the secondary structure of GHSR1b mRNA (the non-spliced type with the 5′UTR microsatellite) among the GHSR1a gene haplotypes. Furthermore, we predicted the potential increase in profitability due to increased carcass weight in cow-calf fattening enterprises through planned matings based on DNA testing of the 5′UTR microsatellite. Statistical analysis revealed that the 5′UTR microsatellite locus had a significant additive effect on carcass weight (CW) and average daily gain (ADG), but not on beef marbling score (BMS). One of the four major microsatellite alleles (19-TG allele) with an allele frequency of 0.145, had a significantly (P < 0.0007) desirable effect on CW and ADG. We concluded that the 19-TG allele could potentially be economically useful nucleotide markers for growth and carcass traits in Japanese Black cattle.

Item Type: Article
Keywords: GHSR, 5’UTR-microsatellite, mRNA secondary structure, growth and carcass traits, Japanese Black cattle
Journal or Publication Title: Animal Science Journal
Page Range: pp. 396-405
ISSN: 1740-0929
Identification Number - DOI: 10.1111/j.1740-0929.2010.00852.x
Additional Information: The definitive published version is available online at: http://onlinelibrary.wiley.com/
Date Deposited: 21 Jun 2011 00:25
Last Modified: 18 Nov 2014 04:18
URI: http://eprints.utas.edu.au/id/eprint/11082
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