Library Open Repository

The effect of transcranial magnetic stimulation on pain and detection thresholds in both healthy individuals and individuals suffering from chronic pain

Downloads

Downloads per month over past year

Colquhoun, S (2009) The effect of transcranial magnetic stimulation on pain and detection thresholds in both healthy individuals and individuals suffering from chronic pain. PhD thesis, University of Tasmania.

[img]
Preview
PDF (Front matter)
01front.pdf | Download (108kB)
Available under University of Tasmania Standard License.

[img] PDF (Whole thesis)
02whole.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.

Abstract

Chronic pain is a complex phenomenon that is thought to affect between
17 and 22% of the Australian population. The complexities of chronic pain and
the many different contributing factors to this condition, makes the relief of the
symptomatic experience of pain difficult in many cases. Although there are a
wide variety of treatment options available with varying degrees of invasiveness,
often these options alone and in combination do not provide adequate pain relief
for chronic pain sufferers.
There is some evidence that repetitive transcranial magnetic stimulation
(rTMS) can alleviate the experience of chronic pain in individuals with
medication-resistant chronic pain. The mechanisms by which rTMS may induce
pain relief, however, are unknown. Consequently, there is a need to further
explore the underlying mechanisms contributing to the analgesic effect that rTMS
displays.
The present research examines the ability of TMS to directly influence
peripheral sensations. The first two studies compared the effects of a single
session of low frequency (1 Hz) TMS and high frequency (20 Hz) rTMS on
thermal sensory thresholds in healthy individuals. High frequency rTMS was
found to produce greater alterations in sensory thresholds than low frequency
rTMS. A third study was carried out examining the effect of a single session of
high frequency (20 Hz) rTMS on the sensory thresholds of individuals suffering
from chronic pain and to measure rTMS-induced changes in their experience of
pain. Overall, this research revealed a limited degree of sensory alteration
following low frequency rTMS in which only cold detection thresholds were
significantly modified. High frequency rTMS, however, significantly altered cold
detection and pain thresholds for healthy individuals, and cold detection, pain and
heat pain thresholds were significantly altered for individuals suffering from
chronic pain. In addition, individuals suffering from chronic pain reported a
significant reduction in their experience of pain following high frequency rTMS.
The finding that rTMS can have a direct effect on sensory thresholds has
implications for the therapeutic use of rTMS in the relief of chronic pain and
provides scope for further investigation into the long-term effects of these
alterations and the use of multiple sessions of rTMS in reducing the experience of
chronic pain.

Item Type: Thesis (PhD)
Additional Information:

Copyright 2009 the Author

Date Deposited: 01 Jul 2011 02:53
Last Modified: 11 Mar 2016 05:53
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page