Library Open Repository

Mendel’s Genes: Toward a Full Molecular Characterization

Downloads

Downloads per month over past year

Reid, JB and Ross, JJ (2011) Mendel’s Genes: Toward a Full Molecular Characterization. Genetics, 189. pp. 3-10. ISSN 0016-6731

[img] PDF
reid.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.

Abstract

The discipline of classical genetics is founded on the hereditary behavior of the seven genes studied by Gregor Mendel. The advent of molecular techniques has unveiled much about the identity of these genes. To date, four genes have been sequenced: A (flower color), LE (stem length), I (cotyledon color), and R (seed shape). Two of the other three genes, GP (pod color) and FA (fasciation), are amenable to candidate gene approaches on the basis of their function, linkage relationships, and synteny between the pea and Medicago genomes. However, even the gene (locus) identity is not known for certain for the seventh character, the pod form, although it is probably V. While the nature of the mutations used by Mendel cannot be determined with certainty, on the basis of the varieties available in Europe in the 1850s, we can speculate on their nature. It turns out that these mutations are attributable to a range of causes—from simple base substitutions and changes to splice sites to the insertion of a transposon-like element. These findings provide a fascinating connection between Mendelian genetics and molecular biology that can be used very effectively in teaching new generations of geneticists. Mendel’s characters also provide novel insights into the nature of the genes responsible for characteristics of agronomic and consumer importance.

Item Type: Article
Journal or Publication Title: Genetics
Page Range: pp. 3-10
ISSN: 0016-6731
Identification Number - DOI: 10.1534/genetics.111.132118
Additional Information: Copyright © 2011 Genetics Society of America
Date Deposited: 24 Nov 2011 23:13
Last Modified: 24 Nov 2011 23:13
URI: http://eprints.utas.edu.au/id/eprint/12300
Item Statistics: View statistics for this item

Repository Staff Only (login required)

Item Control Page Item Control Page