Due to routine maintenance, access to the Library Open Repository will be interrupted on the morning of Friday 12th February.
We apologise for any inconvenience.

Library Open Repository

An ultrastructural and functional assessment of nasal cilia and spermatozoa in an infertile human male and healthy controls


Downloads per month over past year

Harlow, LD and Watkins, WB and Koutoulis, A (2004) An ultrastructural and functional assessment of nasal cilia and spermatozoa in an infertile human male and healthy controls. Papers and Proceedings of the Royal Society of Tasmania, 138. pp. 1-10. ISSN 0080-4703

2004-harlow-ult...pdf | Download (799kB)
Available under University of Tasmania Standard License.


Ciliary disorders are complex and enigmatic, and can lead to and complications. Human males who produce spermatozoa with defective flagella may also possess defective cilia. In this the motility and ultrastructure ofnasal cilia/cells and spermatozoa of an infertile Tasmanian male patient were examined in order to elucidate the cause of his infertility. A detailed examination of the variation in cilia and spermatozoa of control subjects was also conducted. The axonemal structure of all nasal samples from control subjects showed a low frequency of abnormalities; however, when present, abnormalities varied between samples. The nasal cells and spermatozoa of the infertile patient were distinct from control samples, both in terms of motility and ultrastructure. The spermatozoa axonemes of the patient displayed the normal 9+2 microtubule ultrastructure; however, the proportion of immotile spermatozoa and ultrastructural abnormalities was higher than in control samples. All of the patient's nasal cilia were functionally immotile and approximately 70% of ciliated cells displayed extensive ciliary fusion; a feature not found in controls and not previously described. Despite having immotile nasal cilia, this patient was healthy with no obvious respiratory ailments. Additionally, the nasal cells of the patient possessed mitochondria with distended membranes, internalised membranous material, cilia with vesicles and internalised axonemes. These features suggest that ciliary deployment and membrane deposition was compromised in the patient.

Item Type: Article
Keywords: Royal Society of Tasmania, RST, Van Diemens Land, natural history, science, ecology, taxonomy, botany, zoology, geology, geography, papers & proceedings, Australia, UTAS Library
Journal or Publication Title: Papers and Proceedings of the Royal Society of Tasmania
Page Range: pp. 1-10
ISSN: 0080-4703
Collections: Royal Society Collection > Papers & Proceedings of the Royal Society of Tasmania
Additional Information: Copyright Royal Society of Tasmania
Date Deposited: 18 May 2012 02:05
Last Modified: 18 Nov 2014 04:32
Item Statistics: View statistics for this item

Repository Staff Only (login required)

Item Control Page Item Control Page