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Planar microfluidic devices and selective detection in gas chromatography : techniques and applications

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Luong, J (2013) Planar microfluidic devices and selective detection in gas chromatography : techniques and applications. PhD thesis, University of Tasmania.

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Abstract

This graduate research work addresses current techniques and method developments in gas
chromatography. The two major themes of the work are to enhance the chromatographic
performance and reliability of contemporary capillary column chromatography with the use of
planar microfluidic devices, and to garner the power rendered by selective detectors such as
micromachined differential ion mobility detection for the improvement of chromatographic
aspects related to the portability, selectivity, sensitivity, and throughput of analytical systems.
Included in this work are innovative analytical methods developed and successfully implemented
to address difficult, unmet, and unarticulated chromatographic needs that have been encountered
by the community of practice, particularly in the petrochemical and chemical industries.
Over the course of the development of gas chromatography as a technique, many useful
analytical approaches were developed to take advantage of the availability of hundreds of
packing materials employed as stationary phases. However, the tools and devices designed for
the use in column connectivity for the packed column era are not purposely meant for
contemporary capillary column technology. Unfortunately, reliable options are few and far
between. Recent advances in metallurgy, metal injection molding, deactivation chemistry, laser
etching, and diffusion bonding techniques have resulted in the availability of planar microfluidic
devices with features such as built-in fluidic gates, leak-free durability, improved inertness, inoven
and non-contact switching. Therefore, planar microfluidics becomes an important area of
research in chromatography. In this work, the important tactical and strategic use of the
aforementioned devices in capillary gas chromatography was realized with multiple
chromatographic system configurations developed. The use of the device(s) for multi-dimensional gas chromatography, for hyphenated techniques, epitomized by a unified 1D/2D
analytical configuration and two-dimensional gas chromatography – mass spectrometry were
attained.
When properly applied, selective detection can substantially ease the burden of separation
traditionally imposed on the analytical column especially when the matrices of the samples are
increasingly complex to tackle. Selective detection is an enabler to high-speed gas
chromatography which is a key component in the development of portable and hand-held
analytical devices. Therefore, research conducted in this field is not only important but critical
to the capability of and sustainable development for gas chromatography as a technique. In the
current research, the performance, benefit, and impact of using differential ion mobility
spectrometry with resistively heated temperature programmable micromachined gas
chromatography is investigated and its usefulness highlighted. The synergy of hyphenated
techniques with other contemporary selective detectors such as the pulsed sulfur
chemiluminescence detector and mass spectrometry detector operating in selected ion monitoring
mode are also reaffirmed and illustrated in challenging industrial applications.

Item Type: Thesis (PhD)
Keywords: planar microfluidic devices, selective detection, multi-dimensional gas chromatography, selective detection, ultra-trace analysis
Copyright Holders: The Author
Copyright Information:

Copyright 2013 the Author

Date Deposited: 03 Mar 2014 01:00
Last Modified: 03 May 2016 01:04
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