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Emerging technologies in hemostasis diagnostics: A report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group

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Adams, MJ and Ward, C and Thom, J and Bianchi, A and Perrin, E and Coghlan, D and Smith, M (2007) Emerging technologies in hemostasis diagnostics: A report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group. Seminars in Thrombosis and Hemostasis, 33 (3). pp. 226-234. ISSN 0094-6176

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Abstract

Technology in hemostasis laboratories has evolved enormously during the last
30 years. Although many scientists and clinicians will remember the traditional tilt-tube
techniques to screen for coagulation abnormalities and to monitor anticoagulant therapy,
the hemostasis laboratory today uses a variety of modern technologies. These include flow
cytometry, chromogenic assays, molecular typing (e.g., polymerase chain reaction), immunologic
assays (e.g., enzyme-linked immunosorbent assays), functional assays of specific
coagulation proteins, and platelet function analyzers. Although these advances in technology
have resulted in greater capability, productivity, sensitivity, specificity, and ultimately,
improvement in the clinical care of patients, controversies and limitations remain.
This article highlights new and emerging technologies in hemostasis and discusses whether
they have improved or are likely to improve laboratory diagnostics by specifically addressing
the following: (1) Can new technologies help predict likelihood of thrombosis recurrence?
(2) Has an understanding of the role of a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs (ADAMTS13) in microangiopathy resulted in improved
diagnostic methods for this disorder? (3) Does thrombelastography allow better definition
of bleeding risk than conventional hemostasis assays, especially in settings of acute
hemostatic pathology?

Item Type: Article
Keywords: Hemostasis, laboratory testing, thrombin generation, thrombophilia, bleeding
Journal or Publication Title: Seminars in Thrombosis and Hemostasis
Page Range: pp. 226-234
ISSN: 0094-6176
Identification Number - DOI: 10.1055/s-2007-971808
Additional Information:

Copyright 2007, Georg Thieme Verlag. Definitive version is available online at http://www.thieme-connect.de/ejournals/toc/sth/6268

Date Deposited: 12 Sep 2007
Last Modified: 18 Nov 2014 03:21
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