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A comparative study of functional assays for tissue factor pathway inhibitor using normal plasma and clinical samples

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Adams, MJ and Oostryck, R (1999) A comparative study of functional assays for tissue factor pathway inhibitor using normal plasma and clinical samples. Blood Coagulation and Fibrinolysis, 11. pp. 327-333. ISSN 0957 5235

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Abstract

Tissue factor pathway inhibitor (TFPI) is a Kunitz-type inhibitor that regulates the initiation of tissue factor-mediated coagulation. Recent reports in the literature have described variable results using different methodologies for TFPI measurement. In this study, we used one clotting and two amidolytic methodologies to assess TFPI functional levels. The study groups included normal healthy donors as well as patients with acute hepatitis, diabetes, coronary artery bypass graft operations, deep vein thrombosis, and prior to and during heparin therapy. The aims were to compare the results obtained in normal plasma using different assay systems, to compare TFPI levels in a range of clinical samples, including those previously not determined using a clotting methodology, and to report TFPI levels in patient groups previously not investigated. The results clearly demonstrate poor correlation between functional TFPI values using the different methodologies, highlighting the requirement for standardization.

Item Type: Article
Keywords: tissue factor pathway inhibitor, functional assay, thrombosis
Journal or Publication Title: Blood Coagulation and Fibrinolysis
Page Range: pp. 327-333
ISSN: 0957 5235
Date Deposited: 10 Sep 2007
Last Modified: 18 Nov 2014 03:21
URI: http://eprints.utas.edu.au/id/eprint/1813
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