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The combined effect of alcohol and temazepam on information processing

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Declerck, Andre (1993) The combined effect of alcohol and temazepam on information processing. Research Master thesis, University of Tasmania.

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Abstract

The present research investigated the separate and interactive effects
of high doses of a minor tranquilliser (temazepam) (20 mg) and alcohol
(BAC = 0.10%) on human information processing using a dual-task
paradigm.
For this purpose dual task methodology was combined with P300
amplitude and latency as an index of resource allocation. A dual task
paradigm in which subjects were instructed to attend to two tasks
concurrently (which had the effect of increasing overall cognitive load) was
used to indicate if the affects of alcohol and/or temazepam impaired the
contextual updating of neuronal models in the brain and/or reduced
specific 'pools of available resources'.
Twelve subjects completed four drug treatments in a repeated
measures design. The four drug treatments organised in a two by two
design, included a placebo condition (alcohol no/temazepam no), an
alcohol only condition (alcohol yes/temazepam no), a temazepam only
condition (alcohol no/temazepam yes), and a combined condition (alcohol
yes/temazepam yes). Event-related potentials were recorded from midline
sites Fz, Cz and Pz within a dual task paradigm.
The results indicated that at higher doses, widespread neural
depression by alcohol overlapped the specific depressant effects of
temazepam. The effect of ingesting high doses of alcohol and temazepam
was synergistic, that is the combined effects of alcohol and temazepam were
greater than their summated individual effects. In terms of information
processing, from the perspective of contextual updating the process of
updating the pre-existing neuronal model may be restricted, or from the
view of resource allocation the actual pool of available resources may have
been reduced.

The RT data suggested that alcohol and temazepam may have had an
additive effect on psychomotor processing. Both alcohol and temazepam
significantly increased RT when ingested separately, but there was no
interaction between the two drugs. Therefore alcohol and temazepam
appeared to affect different aspects of RT processing.

Item Type: Thesis (Research Master)
Keywords: Alcohol, Temazepam, Human information processing, Drug-alcohol interactions
Copyright Holders: The Author
Copyright Information:

Copyright 1993 the Author - The University is continuing to endeavour to trace the copyright
owner(s) and in the meantime this item has been reproduced here in good faith. We
would be pleased to hear from the copyright owner(s).

Additional Information:

Thesis (M.Psych.)--University of Tasmania, 1994. Includes bibliographical references (leaves 63-81)

Date Deposited: 08 Dec 2014 23:59
Last Modified: 19 Jul 2016 23:54
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