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Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration

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Geraghty, DP and Mazzone, SB (2003) Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration. Brain Research, 979 (1-2). pp. 230-234. ISSN 0006-8993

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Abstract

Binding of [125I]-Bolton–Hunter substance P ([125I]-BHSP), [125I]-neurokinin A and [3H]-senktide to tachykinin NK1, NK2 and NK3 receptors, respectively, was examined in caudal brainstem sections of 10-week-old rats pretreated as neonates (P2) with capsaicin (50 mg/kg, s.c.) or vehicle. [125I]-BHSP binding was localised to the nucleus of the solitary tract (NTS), hypoglossal nucleus and inferior olivary complex, whereas [125I]-neurokinin A and [3H]-senktide binding were confined to the NTS. The distribution and density of binding sites were similar in vehicle- and capsaicin-pretreated rats, suggesting that sensory neuron ablation by neonatal capsaicin does not affect tachykinin receptor numbers in the rat caudal brainstem.

Item Type: Article
Keywords: Neonatal capsaicin; Brain stem; Tachykinin receptors; Autoradiography
Journal or Publication Title: Brain Research
Page Range: pp. 230-234
ISSN: 0006-8993
Identification Number - DOI: 10.1016/S0006-8993(03)02871-3
Additional Information: The definitive version is available at http://www.sciencedirect.com
Date Deposited: 23 Oct 2007 21:51
Last Modified: 18 Nov 2014 03:23
URI: http://eprints.utas.edu.au/id/eprint/2255
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