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Dissecting the genetic architecture of multiple sclerosis


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Lin, R (2014) Dissecting the genetic architecture of multiple sclerosis. PhD thesis, University of Tasmania.

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Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) triggered by environmental and genetic factors. There is considerable
evidence for a significant genetic component to MS susceptibility, such that genome-wide
association studies (GWASs) have successfully revealed about 100 common genetic
variants associated with MS. However, at least 60% of the overall heritability of MS has
not been delineated, so-called “missing heritability”. This thesis describes a series of
experiments to further elucidate the “missing heritability” of MS.

Item Type: Thesis (PhD)
Keywords: Genome wide association studies, Identity-by-descent mapping, whole genome sequencing analysis, gene-environment interaction, pathway analysis, cohort study
Copyright Holders: The Author
Copyright Information:

Copyright 2014 the author

Date Deposited: 29 Sep 2015 02:05
Last Modified: 24 Apr 2016 17:00
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