Please Note:

The Open Access Repository will be moving to a new authentication system on the 1st of November.

From this date onwards, account holders will be required to login using their University of Tasmania credentials.
If your current repository username differs from your University username, please email E.Prints@utas.edu.au so we can update these details on your behalf.

Due to the change, there will be a short outage of the repository from 9am on the morning of the 1st of November

Open Access Repository

Dissecting the genetic architecture of multiple sclerosis

Downloads

Downloads per month over past year

Lin, R (2014) Dissecting the genetic architecture of multiple sclerosis. PhD thesis, University of Tasmania.

[img] PDF (Whole thesis)
Final Thesis.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.

[img]
Preview
PDF (Whole thesis (published material removed))
Lin_whole_thesi...pdf | Download (1MB)
Available under University of Tasmania Standard License.

| Preview

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) triggered by environmental and genetic factors. There is considerable
evidence for a significant genetic component to MS susceptibility, such that genome-wide
association studies (GWASs) have successfully revealed about 100 common genetic
variants associated with MS. However, at least 60% of the overall heritability of MS has
not been delineated, so-called “missing heritability”. This thesis describes a series of
experiments to further elucidate the “missing heritability” of MS.

Item Type: Thesis (PhD)
Keywords: Genome wide association studies, Identity-by-descent mapping, whole genome sequencing analysis, gene-environment interaction, pathway analysis, cohort study
Copyright Holders: The Author
Copyright Information:

Copyright 2014 the author

Date Deposited: 29 Sep 2015 02:05
Last Modified: 24 Apr 2016 17:00
Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP