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Reduced [125 I- Bolton Hunter Substance P Binding (NK1 Receptors) in the Basal Forebrain Nuclei of Aged Rats

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Maguire, CM and Geraghty, DP (2002) Reduced [125 I- Bolton Hunter Substance P Binding (NK1 Receptors) in the Basal Forebrain Nuclei of Aged Rats. Clinical and Experimental Pharmacology and Physiology, 29. pp. 1112-1115. ISSN 1440-1681

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Abstract

1. Quantitative autoradiography and homogenate radioligand
binding of [
125
I]-Bolton Hunter substance P ([
125
I]-BHSP)
were used to compare brain NK
1
receptors in young (2 months)
and aged (18–20 months) rats.
2. The
autoradiographic
distribution
and
density
of
[
125
I]-BHSP binding sites was similar in all cortical regions of
young and aged rats. In contrast, the density of [
125
I]-BHSP
binding sites was significantly (
P
< 0.05) lower in the basal
forebrain nuclei (intermediate part of the lateral septal nuclei,
medial septal nucleus and horizontal and vertical nuclei of the
diagonal band) of aged rats. In all other brain regions
examined, binding densities were almost identical in young and
aged rats.
3. Because a population of NK
1
receptors ([
125
I]-BHSP
binding sites) in the basal forebrain nuclei is associated with
cholinergic neurons, the decrease in NK
1
receptors in aged rats
may reflect degeneration of cholinergic neurons and contribute
to the motor and cognitive deficiencies that occur with ageing.
Key words: ageing, autoradiography, basal forebrain, NK
1
receptor, tachykinin.

Item Type: Article
Journal or Publication Title: Clinical and Experimental Pharmacology and Physiology
Page Range: pp. 1112-1115
ISSN: 1440-1681
Identification Number - DOI: 10.1046/j.1440-1681.2002.03781.x
Additional Information:

The definitive version is available at www.blackwell-synergy.com

Date Deposited: 23 Oct 2007 23:47
Last Modified: 18 Nov 2014 03:24
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