Please Note:

The Open Access Repository will be moving to a new authentication system on the 1st of November.

From this date onwards, account holders will be required to login using their University of Tasmania credentials.
If your current repository username differs from your University username, please email so we can update these details on your behalf.

Due to the change, there will be a short outage of the repository from 9am on the morning of the 1st of November

Open Access Repository

Development of a quantitative technique to assay changes in markers of neural plasticity in response to intermittent theta burst stimulation


Downloads per month over past year

Fulopova, B (2015) Development of a quantitative technique to assay changes in markers of neural plasticity in response to intermittent theta burst stimulation. Honours thesis, University of Tasmania.

PDF (Whole thesis)
Fulopova_whole_...pdf | Download (1MB)
Available under University of Tasmania Standard License.

| Preview


Delivery of intermittent theta burst stimulation (iTBS) can modulate cortical excitability, and if delivered prior to motor training, it can facilitate performance. These effects suggest that iTBS can induce long term potentiation (LTP) like changes within the associated brain areas. However, currently there is a lack of physiological evidence for such processes. Evidence for molecular changes obtained using animal models of iTBS is inconclusive, and methodologically varied. In addition, the use of human sized coil in laboratory rodents further compromises translational merits of obtained findings. Present study is conducted as part of a larger project that uses translational approach to study neurophysiological mechanisms of iTBS in rodents with species specific stimulation coil. Using immunohistochemical analysis of mouse brain sections, changes in presynaptic LTP marker Synaptophysin were investigated in eight animals that demonstrated increased forelimb reaching accuracy over 10 days in a skilled-motor-task after receiving iTBS. Changes in expression of Synaptophysin were compared between three groups (iTBS, sham, handling control), within three brain regions (primary motor cortex, dorsal striatum, piriform cortex). In all three regions, there were no significant differences found between the three groups, suggesting that after 10 days of training, homeostatic process of synaptic scaling may have taken place.

Item Type: Thesis (Honours)
Keywords: iTBS, neuroplasticity, Synaptophysin, motor learning, rTMS,
Copyright Information:

Copyright 2015 the author

Date Deposited: 15 May 2017 07:09
Last Modified: 02 Oct 2017 00:32
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page