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Detection and mapping of QTL on bovine chromosomes 2 and 5 segregating for live weight, average daily gain and body measurements in Japanese Black Cattle

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Malau-Aduli, AEO and Niibayashi, T and Kojima, T and Oshima, K and Mizoguchi, Y and Komatsu, M (2007) Detection and mapping of QTL on bovine chromosomes 2 and 5 segregating for live weight, average daily gain and body measurements in Japanese Black Cattle. Journal of Cell and Animal Biology, 1 (3). 034-043. ISSN 1996-0867

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Abstract

Bovine chromosomes 2 (BTA2) and 5 (BTA5) of purebred, half-sib progeny sired by five Japanese black
bulls were genotyped using microsatellite DNA markers. The data were subjected to linkage analysis for
the detection and mapping of segregating quantitative trait loci (QTL) influencing live weight, average
daily gain and body measurements at weaning. Probability coefficients of inheriting allele 1 or 2 from the
sire at specific chromosomal intervals were computed. The phenotypic data on progeny were regressed on
these probability coefficients in a within-common-parent regression analysis. Fixed effects of sex, parity
and season of birth as well as age as a covariate, were fitted in a linear model to the phenotypic data and
subsequently analysed using QTL Express by generating an F-statistic through permutation tests at
chromosome-wide significance thresholds over 10, 000 iterations at 1 cM intervals. Highly significant
(P<0.01) segregating QTL for body measurements were detected on BTA2 for hip width (1 cM) and chest
depth (8 cM) in Sire Family 1 and pin bone width (16 cM) in Sire Family 3. Other significant QTL (P<0.05)
detected were withers height (3 cM), hip height (4 cM), body length (4 cM), shoulder width (6 cM), lumbar
width (3 cM), thurl width (3 cM) and canon circumference (2 cM) in Sire Family 1, shoulder width (16 cM) in
Sire Family 3 and thurl width (24 cM), pin bone width (19 cM), heart girth (26 cM) and abdominal width (69
cM) in Sire Family 4. Significant (P<0.05) QTL for live weight and average daily gain were detected on BTA2
for birth weight (5 cM) and weaning weight (3 cM) in Sire Family 1 and post-weaning average daily gain (68
cM) in Sire Family 4. BTA 5 contained QTL for birth weight, pin bone width and heart girth in Sire Family 3
that were only suggestive and not significant. Such localization of economically important QTL as
demonstrated in this study, will expedite genetic improvement via marker-assisted selection, gene
introgression and positional cloning in Japanese black cattle.

Item Type: Article
Keywords: QTL mapping, Japanese Black cattle, BTA2, BTA5, body measurements, live weight, daily gain.
Journal or Publication Title: Journal of Cell and Animal Biology
Page Range: 034-043
ISSN: 1996-0867
Date Deposited: 18 Jan 2008 03:06
Last Modified: 18 Nov 2014 03:26
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