Chelation Therapy for Methylmercury(II) Poisoning. Synthesis and Determination of Solubility Properties of MeHg(II) Complexes of Thiol and Dithiol Antidotes
Arnold, AP and Canty, AJ and Moors, PW (1983) Chelation Therapy for Methylmercury(II) Poisoning. Synthesis and Determination of Solubility Properties of MeHg(II) Complexes of Thiol and Dithiol Antidotes. Journal of Inorganic Biochemistry, 19 (4). pp. 319-327.
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Official URL: http://dx.doi.org/10.1016/0162-0134(83)80005-1
Methylmercury complexes of the most widely studied antidotes for mercury poisoning have been prepared, and both the water solubility and l-octanol/water partition coefficients determined for these complexes and the L-cysteine complex. New complexes of N-acetyl-D,L-penicillamine, 2-mercaptosuccinic acid, meso-dimercaptosuccinic acid, and Unithiol have been synthesized and characterized, and are found to have the formulations MeHgSCMe2CH(NHCOMe)CO2H, MeHgSCH(CO2H)CH2CO2H, MeHgSCH(CO2H)CH(CO2H)SHgMe, and Na[MeHgSCH2CH(SHgMe)CH2SO3)], respectively. Trends in octanol/water partition coefficients are consistent with reported studies of the effectiveness of antidotes for methylmercury poisoning and redistribution of methylmercury) on administration of antidotes, particularly for British anti-Lewisite, Unithiol, and meso-dimercaptosuccinic acid.
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|Deposited By:||Prof Allan J Canty|
|Deposited On:||18 Feb 2008 15:24|
|Last Modified:||18 Jul 2008 20:35|
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