Library Open Repository
The analysis of enantiomeric and diastereoisomeric mixtures of ephedrine and pseudoephedrine using reversed-phase HPLC of nickel dithiocarbamate complexes.
Low, GKC and Haddad, PR and Duffield, AM (1983) The analysis of enantiomeric and diastereoisomeric mixtures of ephedrine and pseudoephedrine using reversed-phase HPLC of nickel dithiocarbamate complexes. Journal of Liquid Chromatography, 6 (2). pp. 311-323. ISSN 1520-572X (electronic) 1082-6076 (paper)
021.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.
Following their conversion to dithiocarbamate ligands and thence to nickel complexes, enantiomeric mixtures of ephedrine or pseudoephedrine may be separated and quantitated by reversed-phase High Performance Liquid Chromatography (HPLC) using ternary solvent mixtures. The solvent used to dissolve the complexes prior to injection was found to have a significant effect on the separation. In a similar manner, a mixture of the diastereoisomers ephedrine and pseudoephedrine was separated and quantitatively analysed using a binary solvent as the mobile phase. This separation was achieved both with prior formation of the nickel complexes and also with on-column formation using nickel(II) ions in the mobile phase. The analysis of diastereoisomeric contaminants in pharmaceutical products and raw materials containing ephedrine or pseudoephedrine is illustrated.
|Journal or Publication Title:||Journal of Liquid Chromatography|
|Page Range:||pp. 311-323|
|ISSN:||1520-572X (electronic) 1082-6076 (paper)|
|Identification Number - DOI:||10.1080/01483918308066892|
|Additional Information:||publishers - Taylor & Francis|
|Date Deposited:||13 Mar 2008 01:40|
|Last Modified:||18 Nov 2014 03:31|
|Item Statistics:||View statistics for this item|
Repository Staff Only (login required)
|Item Control Page|