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The analysis of enantiomeric and diastereoisomeric mixtures of ephedrine and pseudoephedrine using reversed-phase HPLC of nickel dithiocarbamate complexes.
Low, GKC and Haddad, PR and Duffield, AM (1983) The analysis of enantiomeric and diastereoisomeric mixtures of ephedrine and pseudoephedrine using reversed-phase HPLC of nickel dithiocarbamate complexes. Journal of Liquid Chromatography, 6 (2). pp. 311-323. ISSN 1520-572X (electronic) 1082-6076 (paper)
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Following their conversion to dithiocarbamate ligands and thence to nickel complexes, enantiomeric mixtures of ephedrine or pseudoephedrine may be separated and quantitated by reversed-phase High Performance Liquid Chromatography (HPLC) using ternary solvent mixtures. The solvent used to dissolve the complexes prior to injection was found to have a significant effect on the separation. In a similar manner, a mixture of the diastereoisomers ephedrine and pseudoephedrine was separated and quantitatively analysed using a binary solvent as the mobile phase. This separation was achieved both with prior formation of the nickel complexes and also with on-column formation using nickel(II) ions in the mobile phase. The analysis of diastereoisomeric contaminants in pharmaceutical products and raw materials containing ephedrine or pseudoephedrine is illustrated.
|Journal or Publication Title:||Journal of Liquid Chromatography|
|Page Range:||pp. 311-323|
|ISSN:||1520-572X (electronic) 1082-6076 (paper)|
|Identification Number - DOI:||10.1080/01483918308066892|
publishers - Taylor & Francis
|Date Deposited:||13 Mar 2008 01:40|
|Last Modified:||18 Nov 2014 03:31|
|Item Statistics:||View statistics for this item|
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