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The analysis of enantiomeric and diastereoisomeric mixtures of ephedrine and pseudoephedrine using reversed-phase HPLC of nickel dithiocarbamate complexes.

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Low, GKC and Haddad, PR and Duffield, AM (1983) The analysis of enantiomeric and diastereoisomeric mixtures of ephedrine and pseudoephedrine using reversed-phase HPLC of nickel dithiocarbamate complexes. Journal of Liquid Chromatography, 6 (2). pp. 311-323. ISSN 1520-572X (electronic) 1082-6076 (paper)

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Abstract

Following their conversion to dithiocarbamate ligands and thence to nickel complexes, enantiomeric mixtures of ephedrine or pseudoephedrine may be separated and quantitated by reversed-phase High Performance Liquid Chromatography (HPLC) using ternary solvent mixtures. The solvent used to dissolve the complexes prior to injection was found to have a significant effect on the separation. In a similar manner, a mixture of the diastereoisomers ephedrine and pseudoephedrine was separated and quantitatively analysed using a binary solvent as the mobile phase. This separation was achieved both with prior formation of the nickel complexes and also with on-column formation using nickel(II) ions in the mobile phase. The analysis of diastereoisomeric contaminants in pharmaceutical products and raw materials containing ephedrine or pseudoephedrine is illustrated.

Item Type: Article
Journal or Publication Title: Journal of Liquid Chromatography
Page Range: pp. 311-323
ISSN: 1520-572X (electronic) 1082-6076 (paper)
Identification Number - DOI: 10.1080/01483918308066892
Additional Information: publishers - Taylor & Francis
Date Deposited: 13 Mar 2008 01:40
Last Modified: 18 Nov 2014 03:31
URI: http://eprints.utas.edu.au/id/eprint/3506
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