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Effect of chronic treatment with clozapine and haloperidol on 5-HT2A and 2C receptor mRNA expression in the rat brain

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Huang, XF and Tan, YY and Huan, X and Wang, Q (2007) Effect of chronic treatment with clozapine and haloperidol on 5-HT2A and 2C receptor mRNA expression in the rat brain. Neuroscience Research, 59 (3). pp. 314-321. ISSN 0168-0102

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Abstract

This study examined regional changes of 5-HT2A and 2C receptor mRNA expression in the rat brain after chronic administration of clozapine (1.5 mg/kg/day) and haloperidol (2.0 mg/kg/day) for 36 days. 5-HT2A and 2C receptor mRNA expression and distributions were detected by in situ hybridization after rats were sacrificed either 2 or 48 h after the last drug administration to examine both immediate and delayed effects following drug withdrawal. Following 2 h of drug withdrawal, it showed that clozapine administration significantly decreased 5-HT2A receptor mRNA, predominantly in the nucleus accumbens (65%), hippocampus (80%), lasteral septal nucleus (61%) and striatum (68%) compared to controls, whilst rebound increases were observed in most of these regions 48 h later. In contrast, no change in 5-HT2A receptor mRNA expression was found in the haloperidol treated groups either 2 h or 48 h after drug withdrawal. Clozapine also decreased 5-HT2C receptor mRNA expression in the posteromedial cortical amygdala (32%) and substantia nigra (35%) 2 h after the last drug administration, while rebound effects were also observed 48 h later. 5-HT2C receptor mRNA was only decreased in the substantia nigra at both 2 h (42%) and 48 h (54%) after the last haloperidol administration. Alterations in serotonin receptor expression in limbic system region such as the nucleus accumbens, hippocampus and lateral septal nucleus as well as the striatum may represent the specific regional targets that mediate the clinical effects of antipsychotics via the serotonin system.

Item Type: Article
Keywords: Antipsychotics; Serotonin receptors; Clozapine; Haloperidol; Schizophrenia; Gene expression Antipsychotics; Serotonin receptors; Clozapine; Haloperidol; Schizophrenia; Gene expression Antipsychotics; Serotonin receptors; Clozapine; Haloperidol; Schizophrenia; Gene expression
Journal or Publication Title: Neuroscience Research
Publisher: Elsevier
Page Range: pp. 314-321
ISSN: 0168-0102
Identification Number - DOI: 10.1016/j.neures.2007.08.001
Additional Information:

The definitive version is available at http://www.sciencedirect.com

Date Deposited: 07 Apr 2008 14:04
Last Modified: 18 Nov 2014 03:33
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