Please Note:

The Open Access Repository will be moving to a new authentication system on the 1st of November.

From this date onwards, account holders will be required to login using their University of Tasmania credentials.
If your current repository username differs from your University username, please email so we can update these details on your behalf.

Due to the change, there will be a short outage of the repository from 9am on the morning of the 1st of November

Open Access Repository

Effect of cloned inhibitor resistant TEM B-lactamases on the susceptibility of H. influenzae to amoxicillin/clavulanate


Downloads per month over past year

Tristram, SG and Burdach, JG (2007) Effect of cloned inhibitor resistant TEM B-lactamases on the susceptibility of H. influenzae to amoxicillin/clavulanate. Journal of Antimicrobial Chemotherapy, 60 (5). pp. 1151-1154. ISSN 0305-7453

3907.pdf | Download (83kB)
Available under University of Tasmania Standard License.

| Preview


Objectives: To determine the effect of cloned inhibitor-resistant TEM b-lactamases (IRTs) on the
susceptibility of Haemophilus influenzae to amoxicillin/clavulanate.
Methods: IRT-2, -4 and -5 genes with various promoters were cloned into control strains of H. influenzae
and the amoxicillin/clavulanate MICs were measured using Etests.
Results: IRT enzymes were able to raise the amoxicillin/clavulanate MICs to between 0.38/0.19 and 4.0/
2.0 mg/L depending on the IRT and promoter genotype, compared with MICs of 0.19/0.09 to 0.5/
0.25 mg/L for the corresponding strains with TEM-1. Strains with an IRT and altered penicillin-binding
proteins had amoxicillin/clavulanate MICs as high as 8.0/4.0 mg/L.
Conclusions: Cloned IRT enzymes in H. influenzae raise the amoxicillin/clavulanate MICs to an extent
comparable to naturally occurring strains with decreased amoxicillin/clavulanate susceptibility.

Item Type: Article
Keywords: H. influenzae, IRTs, susceptibility
Journal or Publication Title: Journal of Antimicrobial Chemotherapy
Publisher: Oxford University Press
Page Range: pp. 1151-1154
ISSN: 0305-7453
Identification Number - DOI: 10.1093/jac/dkm311
Additional Information:

The definitive publisher-authenticated version

Date Deposited: 07 Apr 2008 14:12
Last Modified: 18 Nov 2014 03:33
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page