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Eye movement and visual motion perception in schizophrenia I: Apparent motion evoked smooth pursuit eye movement reveals a hidden dysfunction in smooth pursuit eye movement in schizophrenia

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Slaghuis, WL and Hawkes, AL and Holthouse, TM and Bruno, RB (2007) Eye movement and visual motion perception in schizophrenia I: Apparent motion evoked smooth pursuit eye movement reveals a hidden dysfunction in smooth pursuit eye movement in schizophrenia. Experimental Brain Research, 182 (3). pp. 399-413. ISSN 0014-4819

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Abstract

To date, smooth pursuit eye movement in
schizophrenia has only been investigated using a target
stimulus in continuous motion. However, smooth pursuit
can also be evoked by an oscillating jumping dot that
appears to be in apparent motion and although there is no
continuous motion on the retinal surface this apparently
moving stimulus can eVortlessly elicit smooth-pursuit eye
movement. In the Wrst of two experiments smooth pursuit
eye movement was evoked by target stimuli in continuous
(real) motion at seven target velocities from 5.0 to
35.0 deg/s, and in a second experiment it was measured in
response to an oscillating jumping dot in apparent motion at
eight target velocities from 5.0 to 25.0 deg/s in a group with
mixed-symptoms in schizophrenia and in a control group.
The results of Experiment 1 provided no evidence for a
dysfunction in continuous motion evoked smooth pursuit
eye movement in the group with schizophrenia. However,
following the removal of saccadic eye movements in
smooth pursuit, the group with schizophrenia showed signiWcantly
lower smooth pursuit eye velocity at target velocities
from 20.0 to 35.0 deg/s. The results of Experiment 2
revealed that apparent motion evoked smooth pursuit eye
velocity in the group with schizophrenia was signiWcantly
lower in comparison with normal observers at all target
velocities up to 25.0 deg/s with the inclusion or exclusion
of saccadic eye movements. The Wndings demonstrate that
overall smooth pursuit eye movement evoked in response
to a continuous (real) motion target in the group with
schizophrenia may nevertheless contain a hidden temporal
resolution and integration dysfunction that is revealed when
smooth pursuit eye movement is evoked in response to an
oscillating jumping dot in apparent motion. The Wndings
also demonstrate that normal smooth pursuit eye movement
in normal observers can be made to resemble the dysfunctional
smooth pursuit eye movement that is naturally found
in some people with schizophrenia by using a target stimulus
in apparent motion.

Item Type: Article
Journal or Publication Title: Experimental Brain Research
Publisher: Springer-Verlag
Page Range: pp. 399-413
ISSN: 0014-4819
Identification Number - DOI: 10.1007/s00221-007-1000-6
Additional Information:

The original publication is available at www.springerlink.com

Date Deposited: 07 Apr 2008 14:12
Last Modified: 18 Nov 2014 03:33
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