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Stability of cabergoline in fox baits in laboratory and field conditions

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McLean, SR and Brandon, S and Kirkwood, R (2007) Stability of cabergoline in fox baits in laboratory and field conditions. Wildlife Research, 34 (3). pp. 239-246. ISSN 1035-3712

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Abstract

Cabergoline is a potent inhibitor of prolactin release and a potential fertility control agent for foxes. To understand how cabergoline could behave in baits deployed for fox control, we conducted laboratory and field trials to investigate the stability of cabergoline when (1) in solution, (2) injected into a bait (deep-fried liver and Foxoff®) and (3) exposed to a range of environmental conditions, including burial. Cabergoline, dissolved in a 1% acetic acid solution, and its carboxylic acid hydrolysis product can be assayed using high-performance liquid chromatography. When stored at 4°C and at room temperature, cabergoline in solution was stable for up to 36 days. When stored under cool (≤15°C), dry conditions, cabergoline (800 µg) in commercial Foxoff® and deep-fried ox-liver baits was stable for 28 and 7 days, respectively; stability was reduced by increases in temperature (tested up to 40°C) and humidity. Recovery of cabergoline from buried baits exposed to a range of field conditions decreased rapidly in the first week, but after 56 days remained detectable at levels of 6–22% of the injected amounts. This study has important implications for baiting campaigns that use cabergoline for fox control.

Item Type: Article
Journal or Publication Title: Wildlife Research
Publisher: CSIRO Publishing
Page Range: pp. 239-246
ISSN: 1035-3712
Identification Number - DOI: 10.1071/WR06094
Additional Information:

Copyright © 2007 CSIRO.

Date Deposited: 07 Apr 2008 14:14
Last Modified: 18 Nov 2014 03:33
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