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Increased systemic vascular resistance in Atlantic salmon, Salmo salar L., affected with amoebic gill disease

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Leef, MJ and Hill, JV and Harris, JO and Powell, MD (2007) Increased systemic vascular resistance in Atlantic salmon, Salmo salar L., affected with amoebic gill disease. Journal of Fish Diseases, 30 (10). pp. 601-613. ISSN 0140-7775

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Abstract

Previous investigations into the pathophysiology of
amoebic gill disease (AGD) have suggested that
there are probable cardiovascular effects associated
with this disease. In the present study Atlantic salmon,
Salmo salar L., were experimentally infected by
cohabitation with diseased individuals. Two commonly
used vasodilators, sodium nitroprusside
(SNP) and captopril, the angiotensin-converting
enzyme (ACE) inhibitor, were used as tools to
investigate possible vasoconstriction and/or renin–
angiotensin system (RAS) dysfunction in AGDaffected
animals. Within the SNP trial, results
showed that AGD-affected fish exhibited lowered
cardiac output (Q), lowered cardiac stroke volume
(VS) and a significantly elevated systemic vascular
resistance (RS) compared with non-affected naı¨ve
counterparts. These effects were totally abolished
following SNP administration (40 lg kg)1), however
significant cardiovascular effects associated with
SNP were not observed. Within the captopril trial,
where AGD-affected fish were more diseased compared
with the SNP trial, a significant hypertension
was observed in AGD-affected fish. Captopril
administration (10)4 mol L)1 at 1 mL kg)1)
resulted in a significant drop in dorsal aortic pressure
(PDA) for both AGD-affected and naı¨ve control fish.
In terms of peak individual responses, captopril
administration effectively lowered PDA in both
AGD-affected and naı¨ve control groups equally. The
drop in PDA following SNP administration however
was significantly greater in AGD-affected fish
potentially suggesting disease-related vasoconstriction.
The lack of significant cardiovascular effects
directly associated with both SNP and captopril
administrations possibly relate to the 6 h recovery
period following surgical procedures. However,
while variable, these results do suggest that there are
significant cardiovascular effects including vasoconstriction
and hypertension associated with AGD.

Item Type: Article
Keywords: amoebic gill disease, captopril, cardiovascular dysfunction, Salmo salar, sodium nitroprusside, vasoconstriction
Journal or Publication Title: Journal of Fish Diseases
Publisher: Wiley-Blackwell Publishing Ltd
Page Range: pp. 601-613
ISSN: 0140-7775
Identification Number - DOI: 10.1111/j.1365-2761.2007.00840.x
Additional Information:

The definitive version is available at www.blackwell-synergy.com

Date Deposited: 07 Apr 2008 14:15
Last Modified: 18 Nov 2014 03:33
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