Please Note:

The Open Access Repository will be moving to a new authentication system on the 1st of November.

From this date onwards, account holders will be required to login using their University of Tasmania credentials.
If your current repository username differs from your University username, please email E.Prints@utas.edu.au so we can update these details on your behalf.

Due to the change, there will be a short outage of the repository from 9am on the morning of the 1st of November

Open Access Repository

Potential for endothelin-1-mediated impairment of contractile activity in hypertension

Downloads

Downloads per month over past year

Kolka, CM and Rattigan, S and Richards, SM and Clark, MG (2007) Potential for endothelin-1-mediated impairment of contractile activity in hypertension. Clinical and Experimental Physiology and Pharmacology, 34 (3). pp. 217-222. ISSN 0305-1870

[img] PDF
4066.pdf | Request a copy
Full text restricted

Abstract

The present study examined the potential for reduced
exercise capacity observed in hypertensive patients as a result
of elevated levels of endothelin (ET)-1. We have previously
reported that ET-1 exerts low-dose stimulatory or high-dose
inhibitory effects on the metabolism of the rat isolated perfused
hindlimb from its vasoconstrictor activity.
Herein, we determined whether there are similar effects on
tension development by the rat isolated constant-flow hindlimb
during ET-1-mediated vasoconstriction.
The dose-dependent vasoconstrictor effects of ET-1 on
metabolism in contracting muscle were the same as those
observed previously in resting muscle. Highest concentrations of
ET-1 gave rise to a transient stimulation followed by a marked
inhibition of tension development, consistent with a decrease in
aerobic capacity of the muscle. The vasoconstriction due to the
higher doses of ET-1 was not dilated by electrical stimulation.
In conclusion, the biphasic nature of the actions of ET-1
suggests that although lower concentrations of ET-1 do not affect
exercise capacity, higher concentrations that may occur in
hypertension are inhibitory to metabolism and aerobic capacity
of muscle. The inhibitory effects of ET-1 appear to result from
enhanced functional shunting.

Item Type: Article
Keywords: endothelin, exercise, microcirculation, rats, regional blood flow, vasoconstriction.
Journal or Publication Title: Clinical and Experimental Physiology and Pharmacology
Publisher: Blackwell Publishing
Page Range: pp. 217-222
ISSN: 0305-1870
Identification Number - DOI: 10.1111/j.1440-1681.2007.04575.x
Additional Information:

The original publication is available at
http://www.interscience.wiley.com/

Date Deposited: 07 Apr 2008 14:20
Last Modified: 18 Nov 2014 03:34
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP