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Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats

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Ross, RM and Wadley, GD and Clark, MG and Rattigan, S and McConell, GK (2007) Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats. Diabetes, 56 (12). pp. 2885-2892. ISSN 0012-1797

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Abstract

We have previously shown in humans that local infusion of a nitric oxide synthase (NOS) inhibitor into the femoral artery attenuates the increase in leg glucose uptake during exercise without influencing total leg blood flow. However, rodent studies examining the effect of NOS inhibition on contraction-stimulated skeletal muscle glucose uptake have yielded contradictory results. This study examined the effect of local infusion of an NOS inhibitor on skeletal muscle glucose uptake (2-deoxyglucose) and capillary blood flow (contrast-enhanced ultrasound) during in situ contractions in rats.

Item Type: Article
Journal or Publication Title: Diabetes
Publisher: American Diabetes Association
Page Range: pp. 2885-2892
ISSN: 0012-1797
Identification Number - DOI: 10.2337/db07-0745
Date Deposited: 07 Apr 2008 14:22
Last Modified: 18 Nov 2014 03:34
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