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Evaluation of a compartmental model to describe non-esterified fatty acid kinetics in Holstein dairy cows

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Moate, PJ and Roche, JR and Chagas, LM and Boston, RC (2007) Evaluation of a compartmental model to describe non-esterified fatty acid kinetics in Holstein dairy cows. Journal of Dairy Research, 74. pp. 430-437. ISSN 0022-0299

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Abstract

The dynamics of non-esterified fatty acid (NEFA) metabolism in lactating dairy cows requires
quantification if we are to understand how dietary treatments and disease influence changes in
body condition (adipose reserves) and the production of milk fat. Recently, Thomaseth & Pavan
(2003) presented a compartmental model (Thomaseth model), which employs the pattern of
plasma insulin concentrations in humans to predict the dynamic changes that occur in the
plasma concentrations of glucose and NEFA during an intravenous glucose tolerance test
(IVGTT). The Thomaseth model, or at least a similar model, could have potential application to
the field of energy metabolism in ruminants because it would enable the estimation of
parameters that describe the rates of whole body disposition of glucose, and the production and
utilization of NEFA. In this study we investigated the suitability of the Thomaseth model to
describe NEFA and glucose kinetics in 10 lactating Holstein-Friesian cows given a standard
IVGTT in early lactation. The Thomaseth model described the general pattern of the NEFA
response and, in particular, described the downward-slope and nadir in NEFA concentrations
reasonably well. However, it failed to describe the initial latency period (the period before
NEFA concentrations decline precipitously), and it could not describe terminal ‘rebound’
plateau in NEFA concentration. Because of these inherent problems, the parameters of the
Thomaseth model cannot be considered to provide accurate estimates of rates of NEFA
production or utilization. It is concluded that the Thomaseth model is not suitable for describing
NEFA kinetics in lactating dairy cows.

Item Type: Article
Journal or Publication Title: Journal of Dairy Research
Publisher: Cambridge University Press
Page Range: pp. 430-437
ISSN: 0022-0299
Identification Number - DOI: 10.1017/S0022029907002622
Additional Information:

Copyright© Cambridge University Press

Date Deposited: 07 Apr 2008 14:26
Last Modified: 18 Nov 2014 03:34
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