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The metabolic syndrome and Alzheimer disease


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Razay, G and Vreugdenhil, AJ and Wilcock, G (2007) The metabolic syndrome and Alzheimer disease. Archives of Neurology, 64 (1). pp. 93-96. ISSN 0003-9942

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Background: The metabolic syndrome is a risk factor
for cardiovascular diseases, which have been linked to
Alzheimer disease. However, a link between Alzheimer
disease and the metabolic syndrome has not yet been
Objective: To investigate the relationship between the
metabolic syndrome and Alzheimer disease.
Design, Setting, and Participants: Case-control study
of 50 consecutive patients diagnosed with probable Alzheimer
disease from the Memory Disorders Clinics,
Launceston, Australia, and Bristol, England, and 75 cognitively
normal controls.
Main Outcome Measures: The odds ratio of the metabolic
syndrome as defined by the National Cholesterol
Education Program Adult Treatment Panel III.
Results: Compared with controls, patients with Alzheimer
disease had a significantly larger mean waist circumference,
higher mean plasma concentrations of triglycerides
and glucose, and a lower mean plasma
concentration of high-density lipoprotein cholesterol, but
they had lower mean systolic blood pressure. The metabolic
syndrome was associated with Alzheimer disease
(odds ratio, 3.2; 95% confidence interval, 1.2-8.4; P=.02),
and this association was strengthened when the hypertension
component was excluded (odds ratio, 7.0; 95%
confidence interval, 2.7-18.3; P.001). All of the analyses
were adjusted for age, sex, and location.
Conclusions: This study suggests that Alzheimer disease
is associated with the metabolic syndrome. This could
have implications for the prevention and treatment of
Alzheimer disease.

Item Type: Article
Journal or Publication Title: Archives of Neurology
Publisher: American Medical Association
Page Range: pp. 93-96
ISSN: 0003-9942
Date Deposited: 07 Apr 2008 14:46
Last Modified: 18 Nov 2014 03:36
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