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The toxicology and metabolism of chlorothalonil in fish. 3. Metabolism, enzymatics and detoxication in Salmo spp. and Galaxias spp.

Davies, PE (1985) The toxicology and metabolism of chlorothalonil in fish. 3. Metabolism, enzymatics and detoxication in Salmo spp. and Galaxias spp. Aquatic Toxicology, 7 (4). pp. 277-299.

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Abstract

Hepatic glutathione S-transferase (GST) activity towards chlorothalonil, tetrachloro-isophthalonitrile (TCIN), was established for the five fish species: Salmo gairdneri, S. trutta, Galaxias maculatus, G. truttaceus and G. auratus . Low level exposure to TCIN was found to induce higher GST activity in G. maculatus, G. truttaceus and S. gairdneri . Significant decreases occurred in liver thiol levels of fish when exposed to varying concentrations of TCIN for 96 h without feeding. Liver GSH levels increased in S. gairdneri exposed to 10 mu g/l over 96 h with feeding. A marked increase in GST activity was observed during 96 h exposure to 10 mu g/l. No significant changes in the activity of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) were observed during exposure to 10 mu g/l TCIN in vivo. A transient decrease in activity was observed during exposure to 30 mu g/l TCIN.

Item Type: Article
Keywords: fungicides, enzymatic activity, toxicity tests, sublethal effects, Salmo, Galaxias, Salmo trutta, Galaxias maculatus, Galaxias truttaceus
Journal or Publication Title: Aquatic Toxicology
Page Range: pp. 277-299
Date Deposited: 15 Dec 2006
Last Modified: 16 Mar 2011 02:36
URI: http://eprints.utas.edu.au/id/eprint/468
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