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Monolithic sol-gel microchip device for efficient isolation of nucleic acid from clinical samples

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Wu, Qirong and Breadmore, MC and Hassan, BJ and Giordano, BC and Kwok, YC and Karlinsey, JM and Ferrance, JP and Shrinivasan, S and Norris, PM and Landers, JP (2002) Monolithic sol-gel microchip device for efficient isolation of nucleic acid from clinical samples. In: Micro Total Analysis Systems 2002, 3-7 November, 2002, Nara, Japan.

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Abstract

The feasibility of using monolithic sol-gels for micro-solid phase extraction ({micro}SPE) of deoxyribonucleic acid (DNA) in a microchip format is explored in this work. The monolithic sol-gel bed in a microchip allows efficient DNA purification and extraction with back pressures that are significantly lower than a particle-packed extraction bed. The applicability of the developed {micro}SPE DNA extraction protocol to clinical samples, for example blood and serum, is successfully demonstrated.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Journal or Publication Title: Proceedings of the MicroTAS 2002 Symposium, held in Nara, Japan, 3-7 November 2002
Page Range: pp. 198-200
Date Deposited: 06 Jul 2008 10:16
Last Modified: 18 Nov 2014 03:44
URI: http://eprints.utas.edu.au/id/eprint/6891
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