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Static knee alignment is associated with the risk of unicompartmental knee cartilage defects

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Janakiramanan, N and Teichtahl, AJ and Wluka, AE and Ding, C and Jones, G and Davis, SR and Cicuttini, F (2007) Static knee alignment is associated with the risk of unicompartmental knee cartilage defects. Journal of Orthopaedic Research, 26 (2). pp. 225-230. ISSN 0736-0266

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Abstract

Although knee malalignment is a risk factor for the progression of unicompartmental
knee osteoarthritis (OA), it is unclear how this relationship is mediated. Cartilage defects are known
to predate cartilage loss and the onset of knee OA, and it may be that knee malalignment increases
the risk of unicompartmental knee cartilage defects. Knee radiographs andMRIwere performed on a
total of 202 subjects, 36.6% of whom had radiographic knee OA, to determine the relationship
between static knee alignment and knee cartilage defects. Analyses were performed for the entire
cohort, as well as for healthy andOAsubgroups. For every 18 increase in a valgus direction, there was
an associated reduced risk of the presence of cartilage defects in the medial compartment of subjects
with kneeOA (p¼0.02), healthy subjects (p¼0.002), and the combined (p<0.001) group. Moreover,
for every 18 increase in a valgus direction, there was an associated increased risk of the presence of
lateral cartilage defects in the OA group (p¼0.006), although the relationship between change
toward genu valgum and lateral compartment cartilage defects did not persist for the healthy group
(p¼0.16). This cross-sectional study has demonstrated that knee alignment is associated with the
risk for compartment specific knee cartilage defects in both healthy and arthritic people. Given that
the natural history of cartilage volume reduction appears to be predated by the presence of cartilage
defects, whether knee alignment affects the longitudinal progression from cartilage defects
to cartilage loss requires further examination

Item Type: Article
Keywords: knee; osteoarthritis; alignment; angle; cartilage
Journal or Publication Title: Journal of Orthopaedic Research
Page Range: pp. 225-230
ISSN: 0736-0266
Identification Number - DOI: 10.1002/jor.20465
Additional Information:

The original publication is available at
http://www.interscience.wiley.com/

Date Deposited: 30 Jul 2008 00:02
Last Modified: 18 Nov 2014 03:46
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