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Sorbents with immobilized glycopeptide antibiotics for separating optical isomers by high-performance liquid chromatography

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Kuznetsov, MA and Nesterenko, PN and Vasiyarov, GG and Staroverov, SM (2006) Sorbents with immobilized glycopeptide antibiotics for separating optical isomers by high-performance liquid chromatography. Applied Biochemistry and Microbiology, 42 (6). pp. 536-544. ISSN 0003-6838 (Print) 1608-3024 (Online)

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Abstract

Chiral sorbents for HPLC separation of optical isomers carrying glycopeptide antibiotics (eremomycin or its eremosaminyl aglycon, ristomycin, or vancomycin) fixed onto the surface of silica gel have been synthesized. The patterns of the retention and separation of profen isomers and their dependence on the nature of the chiral selector and the eluant composition have been studied. The sorbents were shown to be highly enantiospecific in separating the isomers of α-amino-, α-hydroxy-, and α-methylphenylcarboxylic acids (profens)

Item Type: Article
Journal or Publication Title: Applied Biochemistry and Microbiology
Page Range: pp. 536-544
ISSN: 0003-6838 (Print) 1608-3024 (Online)
Identification Number - DOI: 10.1134/S0003683806060020
Additional Information: The original publication is available at www.springerlink.com
Date Deposited: 04 Aug 2008 04:31
Last Modified: 18 Nov 2014 03:47
URI: http://eprints.utas.edu.au/id/eprint/7162
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