Please Note:

The Open Access Repository will be moving to a new authentication system on the 1st of November.

From this date onwards, account holders will be required to login using their University of Tasmania credentials.
If your current repository username differs from your University username, please email E.Prints@utas.edu.au so we can update these details on your behalf.

Due to the change, there will be a short outage of the repository from 9am on the morning of the 1st of November

Open Access Repository

Methallothioneins I and II: neuroprotective significance during CNS pathology

Downloads

Downloads per month over past year

Stankovich, J and Chung, RS and Penkowa, M (2007) Methallothioneins I and II: neuroprotective significance during CNS pathology. The International Journal of Biochemistry & Cell Biology, 39 (3). pp. 484-489. ISSN 1357-2725

[img] PDF
stankovic_Int_J...pdf | Request a copy
Full text restricted

Abstract

Metallothioneins (MTs) constitutes a superfamily of highly conserved, low molecular weight polypeptides, which are characterized
by high contents of cysteine (sulphur) and metals. As intracellular metal-binding proteins they playa significant role in the
regulation of essential metals. The major isoforms of the protein (MT-I and MT-II) are induced by numerous stimuli and pathogens
but most importantly their induction by metals is closely linked to the physiological metabolism of zinc and protection from the toxic
affects following heavy metal exposure. Although the preservation of their genetic expression across animal phyla suggests that
MTs may play an important physiological role, MT-I, II knock out (KG) mice survive to adulthood. In both central and peripheral
nervous tissues, MT-I, II have neuroprotective roles, which are also induced by exogenous MT-I and/or MT-II treatment. Hence.
MT-I, II may provide neurotherapeutic targets offering protection against neuronal injury and degeneration.

Item Type: Article
Keywords: Metallothionein; Neurodegenerative diseases; Oxidative stress; Neuronal injury
Journal or Publication Title: The International Journal of Biochemistry & Cell Biology
Page Range: pp. 484-489
ISSN: 1357-2725
Identification Number - DOI: 10.1016/j.biocel.2006.09.010
Additional Information:

The definitive version is available at http://www.sciencedirect.com

Date Deposited: 29 Jul 2008 01:27
Last Modified: 18 Nov 2014 03:47
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP