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Methallothioneins I and II: neuroprotective significance during CNS pathology


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Stankovich, J and Chung, RS and Penkowa, M (2007) Methallothioneins I and II: neuroprotective significance during CNS pathology. The International Journal of Biochemistry & Cell Biology, 39 (3). pp. 484-489. ISSN 1357-2725

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Metallothioneins (MTs) constitutes a superfamily of highly conserved, low molecular weight polypeptides, which are characterized
by high contents of cysteine (sulphur) and metals. As intracellular metal-binding proteins they playa significant role in the
regulation of essential metals. The major isoforms of the protein (MT-I and MT-II) are induced by numerous stimuli and pathogens
but most importantly their induction by metals is closely linked to the physiological metabolism of zinc and protection from the toxic
affects following heavy metal exposure. Although the preservation of their genetic expression across animal phyla suggests that
MTs may play an important physiological role, MT-I, II knock out (KG) mice survive to adulthood. In both central and peripheral
nervous tissues, MT-I, II have neuroprotective roles, which are also induced by exogenous MT-I and/or MT-II treatment. Hence.
MT-I, II may provide neurotherapeutic targets offering protection against neuronal injury and degeneration.

Item Type: Article
Keywords: Metallothionein; Neurodegenerative diseases; Oxidative stress; Neuronal injury
Journal or Publication Title: The International Journal of Biochemistry & Cell Biology
Page Range: pp. 484-489
ISSN: 1357-2725
Identification Number - DOI: 10.1016/j.biocel.2006.09.010
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Date Deposited: 29 Jul 2008 01:27
Last Modified: 18 Nov 2014 03:47
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