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New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica

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Staroverov, SM and Kuznetsov, MA and Nesterenko, PN and Vasiyarov, GG and Katruha, GS and Fedorova, GB (2006) New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica. Journal of Chromatography A, 1108 (2). pp. 263-267. ISSN 0021-9673

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Abstract

A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.

Item Type: Article
Keywords: A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
Journal or Publication Title: Journal of Chromatography A
Page Range: pp. 263-267
ISSN: 0021-9673
Identification Number - DOI: 10.1016/j.chroma.2006.01.073
Additional Information: The definitive version is available at http://www.sciencedirect.com
Date Deposited: 17 Sep 2008 04:34
Last Modified: 18 Nov 2014 03:50
URI: http://eprints.utas.edu.au/id/eprint/7561
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