Library Open Repository

Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study

Downloads

Downloads per month over past year

Zhai, G and Stankovich, J and Cicuttini, F and Ding, C and Jones, G (2006) Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study. Arthritis Research & Therapy, 8 (4). R137. ISSN 1465-9913

[img]
Preview
PDF
Zhai__Arth_Res_Ther.pdf | Download (114kB)

Abstract

The aim of this study was to estimate the heritability and describe the correlates of bone marrow lesions in knee subchondral bone. A sibpair design was used. T2- and T1- weighted MRI scans were performed on the right knee to assess bone marrow lesions at lateral tibia and femora and medial tibia and femora, as well as chondral defects. A radiograph was taken on the same knee and scored for individual features of osteoarthritis (radiographic osteoarthritis; ROA) and alignment. Other variables measured included height, weight, knee pain, and lower-limb muscle strength. Heritability was estimated with the program SOLAR (Sequential Oligogenetic Linkage Analysis Routines). A total of 115 siblings (60 females and 55 males) from 48 families, representing 95 sib pairs, took part. The adjusted heritability estimates were 53 ± 28% (mean ± SEM; p= 0.03) and 65 ± 32% (p = 0.03) for severity of bone marrow lesions at lateral and medial compartments, respectively. The estimates were reduced by 8 to 9% after adjustment for chondral defects and ROA (but not alignment). The adjusted heritability estimate was 99% for prevalent bone marrow lesions at both lateral and medial compartments. Both lateral and medial bone marrow lesions were significantly correlated with age, chondral defects, and ROA of the knee (all p < 0.05). Medial bone marrow lesions were also more common in males and were correlated with body mass index (BMI). Thus, bone marrow lesions have a significant genetic component. They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI.

Item Type: Article
Journal or Publication Title: Arthritis Research & Therapy
Page Range: R137
ISSN: 1465-9913
Identification Number - DOI: 10.1186/ar2027
Date Deposited: 23 Sep 2008 04:48
Last Modified: 18 Nov 2014 03:50
URI: http://eprints.utas.edu.au/id/eprint/7639
Item Statistics: View statistics for this item

Repository Staff Only (login required)

Item Control Page Item Control Page