Due to routine maintenance, access to the Library Open Repository will be interrupted on the morning of Friday 12th February.
We apologise for any inconvenience.

Library Open Repository

Simulation and optimization of retention in ion chromatography using Virtual Column 2 software

Downloads

Downloads per month over past year

Madden, JE and Shaw, MJ and Dicinoski, GW and Avdalovic, N and Haddad, PR (2002) Simulation and optimization of retention in ion chromatography using Virtual Column 2 software. Analytical Chemistry, 74 (23). pp. 6023-6030. ISSN 0003-2700

[img] PDF
292.pdf.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.

Abstract

A new software package, Virtual Column 2, is described for the simulation and optimization of the separation of inorganic anions by ion chromatography (IC). The software uses a limited amount of experimental retention data acquired according to a correct experimental design to predict retention times for analytes over a designated search area of eluent compositions. The experimental retention data are used to solve a new retention model, called the linear solvent strength model, empirical approach (LSSM-EA), which then enables prediction of retention times for all eluent compositions in the search area. The theoretical development of LSSM-EA and the processes used for solving the equations are discussed. Virtual Column 2 can be used for eluents containing one or two competing ions, and the software contains retention databases for up to 33 analytes on the Dionex AS9A-HC, AS4A-SC, and AS14A analytical columns with carbonate-bicarbonate eluents and the Dionex AS10, AS15, and AS16 analytical columns with hydroxide eluents (results for the AS10 and AS15 columns are not discussed in the present study). Virtual Column 2 has been evaluated extensively and is shown to give predicted retention times that in most cases agree with experimentally determined data to within 5%. The software has uses in practical IC method development, education and training in IC, and refinement of existing IC methodology. A free version of this program is available by download at www.virtualcolumn.com.

Item Type: Article
Journal or Publication Title: Analytical Chemistry
Page Range: pp. 6023-6030
ISSN: 0003-2700
Identification Number - DOI: 10.1021/ac020280w
Additional Information: Copyright © 2002 American Chemical Society
Date Deposited: 20 Oct 2008 04:16
Last Modified: 18 Nov 2014 03:52
Item Statistics: View statistics for this item

Repository Staff Only (login required)

Item Control Page Item Control Page