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Column selection for comprehensive multidimensional ion chromatography

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Shellie, RA and Tyrrell, EC and Pohl, CA and Haddad, PR (2008) Column selection for comprehensive multidimensional ion chromatography. Journal of Separation Science, 31 (19). pp. 3287-3296. ISSN 1615-9306

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Abstract

This paper discusses the selection of ion chromatography (IC) columns for use in comprehensive multidimensional ion chromatography (IC×IC). First, a single number was determined for a wide range of anions (one number for each anion) using the linear solvent strength model. These numbers were then used to compare the column selectivity characteristics for five different columns. Principal component analysis was used to illustrate selectivity differences between columns. Dionex AS16 and AS20 columns were selected for use in the development of an IC×IC method for the separation of ten anions. To achieve the required speed of analysis in both the first and second separation dimensions, custom column lengths were packed in-house. The use of an eluent suppressor between the first and second columns permits a relatively low flow ratio regime of only <1:20 in the first and second dimensions, respectively, which reduces dilution effects common in comprehensive multidimensional LC. Selection of the second dimension eluent conditions was aided by the development of a spreadsheet based on the linear solvent strength model.

Item Type: Article
Keywords: Affiliations • Comprehensive two-dimensional • Fast separations • Ion chromatography • Inorganic anions • Selectivity
Journal or Publication Title: Journal of Separation Science
Page Range: pp. 3287-3296
ISSN: 1615-9306
Identification Number - DOI: 10.1002/jssc.200800286
Additional Information: The definitive published version is available online at: http://interscience.wiley.com
Date Deposited: 25 Oct 2008 02:42
Last Modified: 18 Nov 2014 03:52
URI: http://eprints.utas.edu.au/id/eprint/7874
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