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Increased elongase and desaturase gene expression with stearidonic acid enriched diet does not enhance long-chain (n-3) content of seawater Atlantic salmon (Salmo salar L) 1-3

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Miller, MR and Bridle, AR and Nichols, PD and Carter, CG (2008) Increased elongase and desaturase gene expression with stearidonic acid enriched diet does not enhance long-chain (n-3) content of seawater Atlantic salmon (Salmo salar L) 1-3. Journal of Nutrition, 138 (11). pp. 2179-2185. ISSN 0022-3166

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Abstract

Atlantic salmon (Salmo salar L.) can produce (n-3) long-chain (LC)-PUFA when fed biosynthetic precursors. This has potential for developing sustainable aquafeeds. Echium oil (EO) is rich in stearidonic acid [SDA; 18:4(n-3)] and bypasses the initial D6 desaturase (FAD6) step in the (n-3) LC-PUFA biosynthetic pathway. EO was fed to seawater Atlantic salmon for 12 wk and compared with fish fed a diet containing canola oil (CO), a source of a-linolenic acid [ALA; 18:3(n-3)] or fish oil (FO) that provides (n-3) LC-PUFA. Fatty acid (FA) composition of liver, white muscle, and whole fish was measured to show whether dietary precursors were endogenously biosynthesized to LC-PUFA. Gene expression of liver FA elongase and FAD5 was upregulated in EO fish compared with FO fish. Furthermore, dietary precursors affected the FA concentrations of direct biosynthetic products in all tissues. The increased gene expression in the EO fish was reflected by an increased FA concentration of eicosapentaenoic acid [20:5(n-3)] in the liver compared with the CO fish. However, the high concentrations of (n-3) LC-PUFA found in seawater Atlantic salmon fed diets rich in FO were not attained via biosynthesis from precursors (ALA or SDA) in diets. J. Nutr. 138: 2179–2185, 2008.

Item Type: Article
Journal or Publication Title: Journal of Nutrition
Page Range: pp. 2179-2185
ISSN: 0022-3166
Identification Number - DOI: 10.3945/jn.108.091702
Additional Information: Copyright © 2008 the Journal of Nutrition by the American Society for Nutrition
Date Deposited: 26 Nov 2008 00:51
Last Modified: 18 Nov 2014 03:53
URI: http://eprints.utas.edu.au/id/eprint/8066
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