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The role of metallothionein and astrocyte-neuron interactions in injury to the CNS

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Fung, SJ and Chung, RS and West, AK (2008) The role of metallothionein and astrocyte-neuron interactions in injury to the CNS. In: Metallothioneins in Biochemistry and Pathology. World Scientific Publishing Co. Pty Ltd, pp. 117-138. ISBN 978-981-277-893-2

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Abstract

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.

Item Type: Book Section
Publisher: World Scientific Publishing Co. Pty Ltd
Page Range: pp. 117-138
Additional Information: Copyright © 2008 by World Scientific Publishing Co. Pty. Ltd.
Date Deposited: 12 Dec 2008 06:56
Last Modified: 18 Nov 2014 03:54
URI: http://eprints.utas.edu.au/id/eprint/8128
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