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Monthly ambient sunlight, infections and relapse rates in multiple sclerosis

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Tremlett, H and van der Mei, I and Pittas, F and Blizzard, CL and Paley, G and Mesaros, D and Wood-Baker, R and Nunez, M and Dwyer, T and Taylor, BV and Ponsonby, AL (2008) Monthly ambient sunlight, infections and relapse rates in multiple sclerosis. Neuroepidemiology, 31 (4). pp. 271-279. ISSN 0251-5350

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Abstract

Background: Monthly variation in multiple sclerosis (MS) relapses has been found. The relationship between seasonal environmental factors, infections, serum vitamin D [25(OH)D] and MS relapses is undetermined. Methods: We prospectively followed a population-based cohort of relapsing-remitting (RR) MS patients in Southern Tasmania for a mean 2.3 years (January 2002-April 2005). Associations between monthly ambient environmental factors, estimated serum 25(OH)D, upper respiratory tract (URT) infections and relapse rates were examined using weighted Pearson's correlation and linear regression. Results: Of 199 definite MS patients, 142 had RRMS. The lowest relapse rate of 0.5 per 1,000 days (95% CI: 0.2-1.3) occurred in February (mid-late summer) versus the March-January RR of 1.1 per 1,000 days (95% CI: 0.9-1.3; p = 0.018, weighted regression). Monthly relapse rates correlated with: (1) prior erythemal ultraviolet radiation (EUV): lagged 1.5 months, r = -0.32, p = 0.046; (2) URT infection rate: no lag, r = 0.39, p = 0.014; (3) 25(OH)D: no lag, r = -0.31, p = 0.057. The association between URT infections and relapses was reduced after adjustment for monthly EUV. Conclusions: Relapse rates were inversely associated with EUV and serum 25(OH)D levels and positively associated with URT infections. The demonstrated lag between EUV but not 25(OH)D and relapse rates is consistent with a role for EUV-generated 25(OH)D in the alteration of relapse rates. Future work on the association between URT infections and relapses should be considered in the context of ultraviolet radiation and vitamin D.

Item Type: Article
Keywords: Multiple sclerosis, relapsing-remitting Relapse rate Remission rate Meteorological factors Ambient environmental factors Sunlight Erythemal ultraviolet radiation Vitamin D Upper respiratory tract infections
Journal or Publication Title: Neuroepidemiology
Page Range: pp. 271-279
ISSN: 0251-5350
Identification Number - DOI: 10.1159/000166602
Additional Information: Copyright © 2008 S. Karger AG, Basel
Date Deposited: 11 Jan 2009 22:51
Last Modified: 18 Nov 2014 03:54
URI: http://eprints.utas.edu.au/id/eprint/8195
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