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Childhood eczema, asthma incidence and persistence: a cohort study from childhood to middle age

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Burgess, JA and Dharmage, SC and Byrnes, GB and Matheson, MC and Gurrin, LC and Wharton, CL and Johns, DP and Abramson, MJ and Hopper, JL and Walters, EH (2008) Childhood eczema, asthma incidence and persistence: a cohort study from childhood to middle age. Journal of Allergy and Clinical Immunology, 122 (2). pp. 280-285. ISSN 0091-6749

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Abstract

Background: The association between eczema and asthma is well documented, but the temporal sequence of this association has not been closely examined. Objectives: To examine the association between childhood eczema and asthma incidence from preadolescence to middle age, and between childhood eczema and asthma persisting to middle age. A further aim was to examine any effect modification by nonallergic childhood exposures on the association between childhood eczema and both childhood asthma and later life incident asthma. Methods: Data were gathered from the 1968, 1974, and 2004 surveys of the Tasmanian Longitudinal Health Study. Multivariable logistic regression examined the association between childhood eczema and childhood asthma. Cox regression examined the association between childhood eczema and asthma incidence in preadolescence, adolescence, and adult life. Binomial regression examined the association between childhood eczema and childhood asthma persisting to age 44 years. Results: Childhood eczema was significantly associated with childhood asthma and with incident asthma in preadolescence (hazard ratio [HR], 1.70; 95% CI, 1.05-2.75), adolescence (HR, 2.14; 95% CI, 1.33-3.46), and adult life (HR, 1.63; 95% CI, 1.28- 2.09). Although childhood eczema was significantly associated with asthma persisting from childhood to middle age (relative risk, 1.54; 95% CI, 1.17-2.04), this association was no longer evident when adjusted for allergic rhinitis. Conclusion: Childhood eczema increased the likelihood of childhood asthma, of new-onset asthma in later life and of asthma persisting into middle age.

Item Type: Article
Keywords: Childhood eczema, incident asthma, persisting asthma
Journal or Publication Title: Journal of Allergy and Clinical Immunology
Page Range: pp. 280-285
ISSN: 0091-6749
Identification Number - DOI: 10.1016/j.jaci.2008.05.018
Additional Information: The definitive version is available at http://www.sciencedirect.com
Date Deposited: 20 Jan 2009 23:58
Last Modified: 18 Nov 2014 03:55
URI: http://eprints.utas.edu.au/id/eprint/8241
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