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Prediction equations for single breath diffusing capacity (DLCO) in a middle aged caucasian population

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Thompson, BT and Johns, DP and Bailey, M and Raven, J and Walters, EH and Abramson, MJ (2008) Prediction equations for single breath diffusing capacity (DLCO) in a middle aged caucasian population. Thorax, 63 (10). pp. 889-893. ISSN 0040-6376

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Abstract

Background: There are many reference equations for the measurement of single breath carbon monoxide diffusing capacity of the lung (TlCO). However, the testing methodologies vary and there are no well documented studies that have developed reference equations for TlCO and alveolar volume (VA) in middle aged and older populations. Aims: (1) Develop reference equations for TlCO in a middle aged population using the current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines; (2) compare the equations with those commonly used in laboratories around the world. Methods: Healthy subjects (498 male and 474 female) aged 45–71 years were recruited as part of a larger epidemiological study. All participants completed a respiratory questionnaire and had spirometry and single breath TlCO (corrected for haemoglobin) measurements following ATS/ERS guidelines. Results: Mean age was 58 years for males and 57 years for females. For males, factors that predicted TlCO were: height, age, agexheight interaction and being an ex-smoker. For females, factors that predicted TlCO were: height, age, weight and an agexheight interaction. Conclusion: We have described new prediction equations for TlCO in a middle aged population that require validation in other populations.

Item Type: Article
Journal or Publication Title: Thorax
Page Range: pp. 889-893
ISSN: 0040-6376
Identification Number - DOI: 10.1136/thx.2007.091959
Additional Information: Copyright © 2008 BMJ Publishing Group Ltd & British Thoracic Society
Date Deposited: 20 Jan 2009 23:36
Last Modified: 18 Nov 2014 03:55
URI: http://eprints.utas.edu.au/id/eprint/8242
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