Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2006-2008)

Abstract

Poor sensitivity is still considered to be one of the major limitations of electrophoresis, which is surprising given the power, flexibility and versatility of many of the approaches to on-line concentration that have developed over the last 20 years. This is still a very active area of interest and this review will cover developments in the field over the last two years since the last review (Electrophoresis 2007, 28, 254-281) through to June 2008. It includes developments in the fields of stacking, covering all methods from field-amplified sample stacking and large volume sample stacking, through to ITP, dynamic pH junction and sweeping. Attention is also given to on-line or in-line extraction methods that have been used for electrophoresis.