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Platinum versus non-platinum chemotherapy regimens for small cell lung cancer (Review)
Amarasena, IU and Walters, JAE and Wood-Baker, R and Fong, K (2008) Platinum versus non-platinum chemotherapy regimens for small cell lung cancer (Review). Cochrane Database of Systematic Reviews 2008 (4). ISSN 1469-493X
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A comparison of platinum-based and non-platinum-based chemotherapy regimens for the treatment of small cell lung cancer Small cell lung cancer (SCLC) is a very aggressive form of cancer due to early metastasis. As a result, chemotherapy forms the mainstay of treatment. This review compared platinum-based chemotherapy regimens and non-platinum-based chemotherapy regimens for the treatment of SCLC. The results show that there is no significant difference between platinum-based and non-platinum-based chemotherapy regimens in terms of survival and overall (complete and partial) tumour response. However, platinum-based regimens did have better complete tumour response rates. Platinum-based regimens also had higher levels of nausea and vomiting, anaemia and thrombocytopenia toxicity. Further research into the quality of life associated with these treatment regimens is needed.
|Journal or Publication Title:||Cochrane Database of Systematic Reviews 2008|
|Identification Number - DOI:||10.1002/14651858.CD006849.pub2|
|Additional Information:||The definitive published version is available online at: http://interscience.wiley.com|
|Date Deposited:||04 Mar 2009 00:56|
|Last Modified:||18 Nov 2014 03:56|
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