Library Open Repository

Memory loss caused by B-amyloid protein is rescued by a B3-adrenoceptor agonist

Downloads

Downloads per month over past year

Gibbs, ME and Maksel, D and Gibbs, Z and Hou, X and Summers, RJ and Small, DH (2008) Memory loss caused by B-amyloid protein is rescued by a B3-adrenoceptor agonist. Neurobiology of Aging, 31 (4). pp. 614-624. ISSN 0197-4580

[img] PDF
Gibbs_Neuro_Aging.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.

Abstract

Accumulation of the neurotoxic β-amyloid protein (Aβ) in the brain is a key step in the pathogenesis of Alzheimer's disease (AD). Although transgenic mouse models of AD have been developed, there is a clear need for a validated animal model of Aβ-induced amnesia which can be used for toxicity testing and drug development. Intracranial injections of Aβ1–42 impaired memory in a single trial discriminative avoidance learning task in chicks. Memory inhibition was closely associated with the state of aggregation of the Aβ peptide, and a scrambled-sequence of Aβ1–42 peptide failed to impair memory. Aβ had little effect on labile (short-term and intermediate) memory, but blocked consolidation of memory into long-term storage mimicking the type of anterograde amnesia that occurs in early AD. Since noradrenaline exerts a modulatory influence on labile memory in the chick, we examined the effects of two β-adrenoceptor (AR) agonists on Aβ-induced amnesia. A β3-AR agonist (CL316243), but not a β2-AR agonist, rescued Aβ-induced memory loss, suggesting the need for further studies on the role of β3-ARs in AD.

Item Type: Article
Keywords: Chick; Amyloid; Abeta; Dementia; Memory; Alzheimer's disease; Neurotoxicity; Passive avoidance
Journal or Publication Title: Neurobiology of Aging
Page Range: pp. 614-624
ISSN: 0197-4580
Identification Number - DOI: 10.1016/j.neurobiolaging.2008.05.018
Additional Information: The definitive version is available at http://www.sciencedirect.com
Date Deposited: 15 Mar 2009 22:56
Last Modified: 18 Nov 2014 03:56
URI: http://eprints.utas.edu.au/id/eprint/8475
Item Statistics: View statistics for this item

Repository Staff Only (login required)

Item Control Page Item Control Page