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ERM proteins regulate growth cone responses to Sema3A

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Mintz, CD and Carcea, I and McNickle, DG and Dickson, TC and Ge, Y and Salton, SRJ and Benson, DL (2008) ERM proteins regulate growth cone responses to Sema3A. The Journal of Comparative Neurology, 510 (4). pp. 351-366. ISSN 0021-9967

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Abstract

Axonal growth cones initiate and sustain directed growth in response to cues in their environment. A variety of events such as receptor internalization, kinase activation, and actin rearrangement can be stimulated by guidance cues and are essential for mediating targeted growth cone behavior. Surprisingly little is known about how such disparate actions are coordinated. Our data suggest that ezrin, radixin, and moesin (ERMs), a family of highly homologous, multifunctional proteins may be able to coordinate growth cone responses to the guidance cue Semaphorin 3A (Sema3A). We show that active ERMs concentrate asymmetrically in neocortical growth cones, are rapidly and transiently inactivated by Sema3A, and are required for Sema3A-mediated growth cone collapse and guidance. The FERM domain of active ERMs regulates internalization of the Sema3A receptor, Npn1, and its coreceptor, L1CAM, while the ERM C-terminal domain binds and caps F-actin. Our data support a model in which ERMs can coordinate membrane and actin dynamics in response to Sema3A.

Item Type: Article
Keywords: ezrin, axon guidance, actin, L1CAM, neuropilin, LPA
Journal or Publication Title: The Journal of Comparative Neurology
Page Range: pp. 351-366
ISSN: 0021-9967
Identification Number - DOI: 10.1002/cne.21799
Additional Information: The definitive published version is available online at: http://interscience.wiley.com
Date Deposited: 16 Mar 2009 22:04
Last Modified: 18 Nov 2014 03:56
URI: http://eprints.utas.edu.au/id/eprint/8493
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