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Assessment of Thrombin generation: useful or hype?


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Adams, MJ (2009) Assessment of Thrombin generation: useful or hype? Seminars in Thrombosis and Hemostasis, 35 (7). pp. 104-110. ISSN 0094-6176

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Thrombin plays an important role in hemostasis through its multiple functions across blood coagulation, platelet activation, and fibrinolysis. The measurement of thrombin generation is therefore viewed as a potentially useful test that could be applied to the screening, monitoring, and/or diagnosis of hemostatic abnormalities. Indeed, advances in thrombin generation assays have created significant interest and debate as to whether they may provide amore physiologically relevant testing system than do traditional coagulation tests. A variety of thrombin generation assays, including commercially available systems, have been investigated for their correlation with hypocoagulable and hypercoagulable states. Although there is an extensive body of literature that has investigated the application of thrombin generation assays, some limitations remain. These include poor standardization of reagents and methods and a lack of large prospective studies that demonstrate clear relationships between thrombin generation with bleeding and thrombosis phenotypes, as well as with monitoring anticoagulation. Whether thrombin generation assays become more ‘‘useful’’ than ‘‘hype’’ will require well-designed, large, prospective multicenter trials using standardized methods.

Item Type: Article
Journal or Publication Title: Seminars in Thrombosis and Hemostasis
Page Range: pp. 104-110
ISSN: 0094-6176
Identification Number - DOI: 10.1055/s-0029-1214153
Additional Information: Copyright # 2009 by Thieme Medical Publishers, Inc.
Date Deposited: 09 Mar 2010 02:33
Last Modified: 18 Nov 2014 04:09
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