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Thrombosis in systemic lupus erythematosus

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Palatinus, AA and Adams, MJ (2009) Thrombosis in systemic lupus erythematosus. Seminars in Thrombosis and Hemostasis, 35. pp. 621-629. ISSN 0094-6176

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Abstract

Systemic lupus erythematosus (SLE) is a potentially fatal multiorgan inflammatory disease that primarily affects females. Due to the heterogeneity of clinical manifestations and lack of laboratory tests that are both specific and sensitive for the disease, diagnosis of SLE can often be difficult. Although the precise etiology remains to be fully elucidated, it is probable that various environmental, genetic, and hormonal factors contribute to the development of the disease. Patients with SLE have an increased risk for premature thrombosis and/or atherosclerosis, with up to half experiencing a thrombotic event. Furthermore, antiphospholipid antibodies probably play a key role in the development of thrombosis by affecting various hemostatic protein interactions with phospholipids and cell surfaces as well as platelet function. Despite recent advances in knowledge related to the factors that contribute to the pathophysiology of SLE, numerous challenges related to earlier diagnosis as well as the prediction and prevention of thrombotic events remain to be fully addressed.

Item Type: Article
Keywords: Systemic lupus erythematosus, lupus, thrombosis, antiphospholipid antibody
Journal or Publication Title: Seminars in Thrombosis and Hemostasis
Page Range: pp. 621-629
ISSN: 0094-6176
Identification Number - DOI: 10.1055/s-0029-1242716
Additional Information: © 2009 by Thieme Medical Publishers, Inc. Definitive version available at www.thieme-connect.com
Date Deposited: 31 Mar 2010 03:00
Last Modified: 18 Nov 2014 04:09
URI: http://eprints.utas.edu.au/id/eprint/9647
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