TY  - JOUR
ID  - epprod3792
UR  - http://dx.doi.org/10.1016/j.jaci.2007.07.020
IS  - 4
A1  - Burgess, JA
A1  - Dharmage, SC
A1  - Walters, EH
A1  - Byrnes, GB
A1  - Matheson, MC
A1  - Jenkins, MA
A1  - Wharton, CL
A1  - Johns, DP
A1  - Abramson, MJ
A1  - Hopper, JL
N2  - Background: The association between allergic rhinitis and
asthma is well documented, but the temporal sequence of this
association has not been closely examined.
Objective: We sought to assess the associations between
childhood allergic rhinitis and (1) asthma incidence from
preadolescence to middle age and (2) asthma persistence to
middle age.
Methods: Data were gathered from the 1968, 1974, and 2004
surveys of the Tasmanian Asthma Study. Cox regression was
used to examine the association between childhood allergic
rhinitis and asthma incidence in preadolescence, adolescence,
and adult life. Binomial regression was used to examine the
association between childhood allergic rhinitis and asthma
beginning before the age of 7 years and persisting at age 44
years.
Results: Childhood allergic rhinitis was associated with a
significant 2- to 7-fold increased risk of incident asthma in
preadolescence, adolescence, or adult life. Childhood allergic
rhinitis was associated with a 3-fold increased risk of childhood
asthma persisting compared with remitting by middle age.
Conclusions: Childhood allergic rhinitis increased the
likelihood of new-onset asthma after childhood and the
likelihood of having persisting asthma from childhood into
middle age.
Clinical implications: Asthma burden in later life might be
reduced by more aggressive treatment of allergic rhinitis in
early life. (J Allergy Clin Immunol 2007;120:863-9.)
Key words: Childhood allergic rhinitis, incident asthma, persisting
asthma, effect modification
VL  - 120
TI  - Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: A longitudinal study
AV  - restricted
EP  - 869
N1  - The definitive version is available at http://www.sciencedirect.com
Y1  - 2007///
PB  - Mosby, Inc.
JF  - Journal of Allergy and Clinical Immunology
KW  - Childhood allergic rhinitis
KW  -  incident asthma
KW  -  persisting
asthma
KW  -  effect modification
SN  - 0091-6749
SP  - 863
ER  -