http://eprints.utas.edu.au/6138/ Chemical and physical processes for integrated temperature control in microfluidic devices Guijt, RM Dodge, A van Dedem, GWK de Rooij, NF Verpoorte, E 250000 Chemical Sciences 250401 Separation Science 250400 Analytical Chemistry Microfluidic devices are a promising new tool for studying and optimizing (bio)chemical reactions and analyses. Many (bio)chemical reactions require accurate temperature control, such as for example thermocycling for PCR. Here, a new integrated temperature control system for microfluidic devices is presented, using chemical and physical processes to locally regulate temperature. In demonstration experiments, the evaporation of acetone was used as an endothermic process to cool a microchannel. Additionally, heating of a microchannel was achieved by dissolution of concentrated sulfuric acid in water as an exothermic process. Localization of the contact area of two flows in a microfluidic channel allows control of the position and the magnitude of the thermal effect. 2003-02 Article PeerReviewed application/pdf http://eprints.utas.edu.au/6138/1/RMG10.pdf http://dx.doi.org/10.1039/b210629a Guijt, RM and Dodge, A and van Dedem, GWK and de Rooij, NF and Verpoorte, E (2003) Chemical and physical processes for integrated temperature control in microfluidic devices. Lab on a Chip, 3 (1). pp. 1-4. ISSN print 1473-0197; online 1473-0189 http://eprints.utas.edu.au/6138/http://eprints.utas.edu.au/6138/1/