TY  - JOUR
N1  - The definitive version is available online at http://www.sciencedirect.com/
ID  - epprod6424
UR  - http://dx.doi.org/10.1016/S0021-9673(01)00855-X
IS  - 1-2
A1  - Murrihy, JP
A1  - Breadmore, MC
A1  - Tan, A
A1  - McEnery, M
A1  - Alderman, J
A1  - O'Mathuna, C
A1  - O'Neill, AP
A1  - O'Brien, P
A1  - Avdalovic, N
A1  - Haddad, PR
A1  - Glennon, JD
Y1  - 2001/07/27/
N2  - On-chip separation of inorganic anions by ion-exchange chromatography was realized. Micro separation channels were fabricated on a silicon wafer and sealed with a Pyrex cover plate using standard photolithography, wet and dry chemical etching, and anodic bonding techniques. Quaternary ammonium latex particles were employed for the first time to coat the separation channels on-chip. Owing to the narrow depths of the channels on the chip, 0.5?10 ?m, there were more interactions of the analytes with the stationary phase on the chip than in a 50-?m I.D. capillary. With off-chip injection (20 nl) and UV detection, NO2?, NO3?, I?, and thiourea were separated using 1 mM KCl as the eluent. The linear ranges for NO2? and NO3? are from 5 to 1000 ?M with the detection limits of 0.5 ?M.
JF  - Journal of Chromatography A
VL  - 924
KW  - Inorganic anions; Thiourea; Chip technology; Instrumentation; Latex nanoparticles; Microseparation
SN  - 0021-9673
TI  - Ion chromatography on-chip
SP  - 233
AV  - restricted
EP  - 238
ER  -