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Factors Affecting the Stability of Blood Lipid and Lipoprotein Levels From Youth to Adulthood

Magnussen, CG, Thomson, RJ, Cleland, VJ, Ukoumunne, O, Dwyer, T and Venn, AJ 2011 , 'Factors Affecting the Stability of Blood Lipid and Lipoprotein Levels From Youth to Adulthood' , Archives of Pediatrics & Adolescent Medicine, vol. 165 , pp. 68-76 .

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Objective: To examine the effect of lifestyle changes on
the stability of blood lipid and lipoprotein levels from
youth to adulthood.
Design: Prospective cohort study.
Setting: Australia.
Participants: Five hundred thirty-nine young adults who
underwent measurement at baseline in 1985 when aged
9, 12, or 15 years and again at follow-up between 2004
and 2006.
Main Exposures: Changes in adiposity, cardiorespiratory
fitness, saturated fat intake, smoking, and socioeconomic
Main Outcome Measures: Child and adult blood lipid
Results: Using established cut points, we found that substantial proportions of individuals with high-risk blood
lipid and lipoprotein levels at baseline no longer had highrisk levels at follow-up. Of the participants who had highrisk levels in youth, those with greater increases in adiposity or who commenced or continued smoking were
more likely to maintain high-risk blood lipid and lipoprotein levels (P.05). Participants who became high
risk at follow-up had greater increases in adiposity, were
less likely to improve their socioeconomic position, and
tended to become less fit between surveys compared with
those who maintained normal-risk levels (P.05). These
effects tended to remain (P.10) after adjustment for
all predictive lifestyle variables.
Conclusions: Unhealthy lifestyle changes that occur between
youth and adulthood affect whether an individual maintains, loses, or develops high-risk blood lipid and lipoprotein levels in adulthood. Interventions that promote weight control in the first instance, but also physical activity, not smoking, and improved socioeconomic position in the transition from youth to adulthood, are likely to be of benefit in preventing adult dyslipidemia.

Item Type: Article
Authors/Creators:Magnussen, CG and Thomson, RJ and Cleland, VJ and Ukoumunne, O and Dwyer, T and Venn, AJ
Keywords: CDAH
Journal or Publication Title: Archives of Pediatrics & Adolescent Medicine
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