Preview	PDF (Title, Dedication, Abstract, Contents, Preface) Front_matter.pdf | Download (306kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 1 - Data Synthesis in Medicine) Part_I_Ch_1_SDE...pdf | Download (263kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 2 - Scientific Method : A Solution) Part_I_Ch_2_Nov...pdf | Download (229kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 4 - Atherosclerosis) Part_II_Ch_4_No...pdf | Download (275kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 3 - Stress and Disease: the Development of a Vasospastic Theory) Part_II_Ch_3_No...pdf | Download (260kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 5 - Vasospasm and General Arterial Disease) Part_II_Ch_5_No...pdf | Download (228kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 6 - Stress, Vasospasm and General Disease) Part_II_Ch_6_No...pdf | Download (406kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 7 - Beyond Interpretation) Part_III.Ch.7.pdf | Download (147kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 8 - Evolution: The Problem) Part_III_Ch_8_N...pdf | Download (315kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 9 - Evolution: A Viral Theory) Part_III_Ch_9_N...pdf | Download (517kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 10- Beyond Interpretation) PartIII_Ch_10_1...pdf | Download (153kB) Available under University of Tasmania Standard License.
Preview	PDF (Chapter 11 - Theory formulation in medical science) Part_III_Ch_11_...pdf | Download (79kB) Available under University of Tasmania Standard License.

Abstract

I present a perspective on disease mechanisms developed over my years of clinical experience. In Part I, I look at the history of data synthesis in medicine and medical science, and find it to be rather haphazard. I suggest a new way of building up the clinical information to a reasonable conclusion based on individual patient data. Part II then applies that approach to understanding disease mechanisms, and concludes that arterial constriction, caused largely by sympathetic activation under the influence of stress, is likely to be an important initiating factor in many cardiovascular diseases, particularly heart attack and stroke. I go on to look at the possible role of such vasoconstriction in other disease. Part III suggests that arterial constriction may even be important in cancer pathogenesis and evolutionary mechanisms, through ischemic (blood flow reduction) destabilisation of a genome composed essentially of naturally genetically-engineered viral modules. The important conclusion then is that evolution is perhaps best seen as natural genetic engineering.

Item Type:	Book
Authors/Creators:	Boyd, GW
Publisher:	GW Boyd
Additional Information:	ePrints links for other publications by this author: "Making Physiology Work in Clinical Diagnosis": http://eprints.utas.edu.au/15540/ . Clinical Diagnostic Reasoning: a novel online tutorial system for interactive learning: http://eprints.utas.edu.au/12445/ . The Body, Its Emotions, the Self, and Consciousness: http://eprints.utas.edu.au/15837/ . Education debate: clinical diagnostic reasoning: http://eprints.utas.edu.au/12436/ . Clinical Method: A guide for medical students: http://eprints.utas.edu.au/15630/ .
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